A convergent fabrication of programmed pH/reduction-responsive nanoparticles for efficient dual anticancer drugs delivery for ovarian cancer treatment

A nanoparticle-based drug delivery technology could develop combination cancer therapy more effectively. However, because of inadequate into tumor cells, the therapeutic efficiency nanomedicines is diminished. PEGylated poly(α-lipoic acid) copolymers with (mPEG-PLA) were fabricated and used as pH/reductive responsive nanovesicles to administer Gefitinib (GFT) doxorubicin (DOX) for treatment ovarian cancer. The amphiphilic polymers mPEG-PLA may be efficiently incorporated on DOX GFT fabricate coloaded nanoparticles (DOX@GFT-NPs) self-assembled an aqueous solution. DOX@GFT-NPs released after being prepared respond pH reduction stimuli. outcomes confocal laser scanning microscopy flow cytometry findings, SKOV3 cells quickly fascinated dual drugs-coloaded drugs intracellularly accumulated. triggered cell death demonstrated synergistic benefits in cells. Results showed that trigger apoptosis using morphological staining (acridine orange/ethidium bromide (AO/EB) HOECHST 33342 nuclear staining). These show stimuli copolymer treat a promising approach.